USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P30041 USC-OGP 2-DE database:  P30041 P30041 General information about the entry View entry in simple text format Entry name PRDX6_HUMAN Primary accession number P30041 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Peroxiredoxin-6; EC=1.11.1.15; AltName: Full=1-Cys peroxiredoxin; Short=1-Cys PRX; AltName: Full=24 kDa protein; AltName: Full=Acidic calcium-independent phospholipase A2; Short=aiPLA2; EC=3.1.1.-; AltName: Full=Antioxidant protein 2; AltName: Full=Liver 2D page spot 40; AltName: Full=Non-selenium glutathione peroxidase; Short=NSGPx; EC=1.11.1.9; AltName: Full=Red blood cells page spot 12;. Gene name Name=PRDX6 Synonyms=AOP2, KIAA0106 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0517: pI=6.05; Mw=26242 SPOT OGP-0522: pI=5.79; Mw=25785 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0796: pI=5.77; Mw=29597 SPOT OGP-0803: pI=5.75; Mw=27642 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1010: pI=6.04; Mw=26148 SPOT OGP-1011: pI=6.60; Mw=26072 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1269: pI=6.38; Mw=28709 SPOT OGP-1282: pI=6.89; Mw=26515 SPOT OGP-1343: pI=5.74; Mw=15018 Cross-references UniProtKB/Swiss-Prot P30041; PRDX6_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PRDX6_HUMAN Primary accession number P30041 Secondary accession number(s) A8JZY7 P32077 Q5TAH4 Q5ZEZ8 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 186) Name and origin of the protein Description RecName: Full=Peroxiredoxin-6; EC=1.11.1.15; AltName: Full=1-Cys peroxiredoxin; Short=1-Cys PRX; AltName: Full=24 kDa protein; AltName: Full=Acidic calcium-independent phospholipase A2; Short=aiPLA2; EC=3.1.1.-; AltName: Full=Antioxidant protein 2; AltName: Full=Liver 2D page spot 40; AltName: Full=Non-selenium glutathione peroxidase; Short=NSGPx; EC=1.11.1.9; AltName: Full=Red blood cells page spot 12; Gene name Name=PRDX6 Synonyms=AOP2, KIAA0106 Encoded on Name=PRDX6; Synonyms=AOP2, KIAA0106 Keywords 3D-structure; Acetylation; Antioxidant; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Disulfide bond; Hydrolase; Lipid degradation; Lipid metabolism; Lysosome; Multifunctional enzyme; Oxidoreductase; Peroxidase; Phosphoprotein; Redox-active center; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D14662; BAA03496.1; -; mRNA EMBL DQ230990; ABB02185.1; -; Genomic_DNA EMBL AL139142; CAI20936.1; -; Genomic_DNA EMBL AK289352; BAF82041.1; -; mRNA EMBL CH471067; EAW90944.1; -; Genomic_DNA EMBL BC035857; AAH35857.1; -; mRNA EMBL BC053550; AAH53550.1; -; mRNA EMBL AJ844621; CAH59743.1; -; mRNA CCDS CCDS1307.1; -; . RefSeq NP_004896.1; NM_004905.2; . UniGene Hs.120; -; . UniGene Hs.731505; -; . PDB 1PRX; X-ray; 2.00 A; A/B=1-224 PDB 5B6M; X-ray; 2.50 A; A/B/C/D/E/F=1-224 PDB 5B6N; X-ray; 2.90 A; A/B/C/D/E/F=1-224 PDBsum 1PRX; -; . PDBsum 5B6M; -; . PDBsum 5B6N; -; . ProteinModelPortal P30041; -; . SMR P30041; -; . BioGrid 114956; 80; . IntAct P30041; 23; . MINT MINT-4999165; -; . STRING 9606.ENSP00000342026; -; . DrugBank DB03814; 2-(N-Morpholino)-Ethanesulfonic Acid; . DrugBank DB02325; Isopropyl Alcohol; . PeroxiBase 4426; Hs1CysPrx01; . iPTMnet P30041; -; . PhosphoSitePlus P30041; -; . SwissPalm P30041; -; . BioMuta PRDX6; -; . DMDM 1718024; -; . DOSAC-COBS-2DPAGE P30041; -; . OGP P30041; -; . REPRODUCTION-2DPAGE IPI00220301; -; . REPRODUCTION-2DPAGE P30041; -; . SWISS-2DPAGE P30041; -; . EPD P30041; -; . PaxDb P30041; -; . PeptideAtlas P30041; -; . PRIDE P30041; -; . TopDownProteomics P30041; -; . DNASU 9588; -; . Ensembl ENST00000340385; ENSP00000342026; ENSG00000117592; . GeneID 9588; -; . KEGG hsa:9588; -; . CTD 9588; -; . DisGeNET 9588; -; . GeneCards PRDX6; -; . H-InvDB HIX0028696; -; . HGNC HGNC:16753; PRDX6; . HPA CAB008663; -; . HPA HPA006983; -; . MIM 602316; gene; . neXtProt NX_P30041; -; . OpenTargets ENSG00000117592; -; . PharmGKB PA134992760; -; . eggNOG KOG0854; Eukaryota; . eggNOG COG0450; LUCA; . GeneTree ENSGT00550000074794; -; . HOGENOM HOG000022346; -; . HOVERGEN HBG105234; -; . InParanoid P30041; -; . KO K11188; -; . OMA QLTDNYS; -; . OrthoDB EOG091G0IWK; -; . PhylomeDB P30041; -; . TreeFam TF105183; -; . BRENDA 1.11.1.15; 2681; . Reactome R-HSA-3299685; Detoxification of Reactive Oxygen Species; . Reactome R-HSA-6798695; Neutrophil degranulation; . SIGNOR P30041; -; . ChiTaRS PRDX6; human; . EvolutionaryTrace P30041; -; . GeneWiki PRDX6; -; . GenomeRNAi 9588; -; . PRO PR:P30041; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000117592; -; . CleanEx HS_PRDX6; -; . ExpressionAtlas P30041; baseline and differential; . Genevisible P30041; HS; . GO GO:0035578; C:azurophil granule lumen; TAS:Reactome; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; NAS:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0004602; F:glutathione peroxidase activity; IEA:UniProtKB-EC; . GO GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW; . GO GO:0051920; F:peroxiredoxin activity; IEA:UniProtKB-EC; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL; . GO GO:0045454; P:cell redox homeostasis; IEA:InterPro; . GO GO:0042744; P:hydrogen peroxide catabolic process; IEA:Ensembl; . GO GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0000302; P:response to reactive oxygen species; TAS:Reactome; . Gene3D 3.40.30.10; -; 1; . InterPro IPR000866; AhpC/TSA; . InterPro IPR024706; Peroxiredoxin_AhpC-typ; . InterPro IPR019479; Peroxiredoxin_C; . InterPro IPR012336; Thioredoxin-like_fold; . InterPro IPR013766; Thioredoxin_domain; . Pfam PF10417; 1-cysPrx_C; 1; . Pfam PF00578; AhpC-TSA; 1; . PIRSF PIRSF000239; AHPC; 1; . SUPFAM SSF52833; SSF52833; 1; . PROSITE PS51352; THIOREDOXIN_2; 1; .

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